When large dogs eliminate, they eliminate a lot more than small dogs. More goes in and more comes out of large breeds. Which is something to keep in mind if your dog will live inside - especially if you live in a high rise apartment and he will have to be litter box trained (there is always going to be more to clean up).
Other breeding bills lump small breeders in with large commercial breeders. Small breeders are in no any way able to meet some of the kennel requirements written for large commercial establishments because they typically keep their dogs in their home as pets.
All dogs should get as much exercise as possible. A daily walk is sufficient for most breeds. But most small dog breeds, for example Toy dogs such as Pugs, Maltese or Yorkshire Terriers, will get the majority of their required exercise needs just be walking, running and playing around indoors.
If you do not have time to exercise your dog daily with a brisk walk and lots of running choose a breed that does not have high exercise requirements. All of the breeds who require high amounts of exercise make terrific jogging, hiking, and ridding companions. So if you want your dog to accompany you on long runs choose one of these highly active breeds built for endurance and as much exercise as you can throw at them - they will love you for it (and a tired dog is not destructive).