When large dogs eliminate, they eliminate a lot more than small dogs. More goes in and more comes out of large breeds. Which is something to keep in mind if your dog will live inside - especially if you live in a high rise apartment and he will have to be litter box trained (there is always going to be more to clean up).
Most all dogs will get along well with children if they are raised with them. However, some breeds have a protective streak in them and may become aggressive with children who get to close at meal time (although this should not be tolerated), or aggressive with children they have never met. These breeds will likely see the children as being underneath themselves in the "pack order" and may try to dominate them.
Keep in mind that large dogs are more expensive to keep. They eat more food, which costs you more money. Tick and flea preventives cost more for large dogs, as do other mediations.
So keep in mind that if you choose a breed with a long coat you will either need to get it clipped regularly if you want to avoid brushing it so much, or if you choose to keep it long or even medium length you will have to brush it every day.
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